Explaining Which Muscles Are Hit Hardest in SMA?
One of the most important things to understand about SMA is that it often affects the muscles closest to the center of the body the hardest. Muscle weakness in SMA tends to be more severe in proximal muscles — the muscles near the body’s center — compared to distal muscles farther away from the center.
SMA weakens the muscles closest to the center of the body, including the shoulders, hips, thighs, and upper back. This can affect everyday tasks such as sitting upright, holding the head up, lifting the arms, reaching, transferring, standing, walking, coughing, and taking deep breaths. The lower limbs may be affected more than the upper limbs, which helps explain why walking, standing, balance, and leg strength can become major challenges for many people living with SMA.
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